Siân Ratcliffe, PhD
SVP, Head of Quantitative Sciences & Development Operations
Biogen
Siân is currently SVP, Head of Quantitative Sciences & Development Operations (QSDO) at Biogen, where she leads a global team accountable for the strategic planning, execution and analysis of clinical trials across all phases of development and therapeutic areas, ie MS/Immunology, Rare Disease (Neuromuscular Disorders, Genetic Neurodevelopmental Disorders) and Neuroscience (Alzheimer’s Disease, Movement Disorders, Psychiatry). Siân and her team are driving numerous innovation projects to transform clinical trials and accelerate clinical development.
Prior to Biogen, Siân spent 20+ years Pfizer, where she held senior leadership and group head roles in Clinical Operations, Medical Writing, Clinical Development, Preclinical Safety (Toxicology and Safety Pharmacology), Safety Risk Management and Regulatory Strategy, managing projects throughout development stages from research to post-approval in multiple therapeutic areas (including Oncology, Neurology, Psychiatry, Pain, Rare Disease, Immunology, Internal Medicine, Women’s Health and Vaccines). In addition, Siân has co-led a number of cross-industry initiatives for TransCelerate, BIO, ICH and public-private partnerships to advance clinical trial innovation approaches, precision medicine drug development and translational sciences.
Siân has a PhD in Pharmacology from the University of Cambridge where she also held post-doctoral research and academic posts. Siân also serves on the Executive Committee as Treasurer for the International Society for CNS Clinical Trials Methodology (ISCTM), co-leads the ISCTM CNS Clinical Trial Diversity Working Group and mentors new investigators involved in psychiatry and neurology research.