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2019 Agenda

  • 8:00 am

  • Registration and Morning Coffee/Tea

  • 8:30 am

  • Co-Chairs Opening Remarks

    Ann Daugherty
    Ann Daugherty, PhD

    Senior Manager, Drug Delivery, Genentech

    James Cunningham
    James Cunningham, PhD

    Executive Director, Drug Delivery, Allergan


  • Keynotes, Intracellular Delivery, Brain Delivery, Peptide & Ophthalmology Delivery Alternatives and Pharma Delivery Needs & Partnering

  • 8:40 am

  • Keynote: State of the Industry Address & Nano-medicine’s Current Clinical Reality: An Analysis of Recent Results


    David W Grainger, PhD

    University Distinguished Professor, Chair, Department of Biomedical Engineering, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah

  • 9:20 am

  • Intracellular and Tissue Specific Delivery of Therapeutic Payloads

    • Targeted Therapeutics team at Janssen is focused on addressing the challenges of intracellular and tissue specific delivery across modality spectrum
    • A focus on understanding parameters of receptor-specific uptake and internalization and using relevant assays for proper ligand selection
    • Examples of using these methods for specific functional delivery of nucleic acids and nanoparticles


    Vadim Dudkin, PhD

    Head of Targeted Therapeutics at Janssen Discovery Sciences, Johnson & Johnson

  • 9:40 am

  • Morning Networking Break

  • 10:20 am

  • Keynote: MRI-Guided Focused Ultrasound and the Delivery of Therapeutics to the Brain

    Dr Isabelle Aubert, University of Toronoto, will provide an introduction to MRI-guided focused ultrasound (MRIgFUS), which in presence of intravenously injected phospholipid microspheres is used to increase the permeability of the blood-brain barrier (BBB) in a localized, controlled, and transient manner. She will review applications in preclinical models of neurodegenerative disorders where therapeutic molecules, gene therapy vectors, and progenitor cells are injected intravenously and delivered from the blood to targeted areas of the brain with MRIgFUS. Dr Aubert will describe the seminal work of the Sunnybrook team on MRIgFUS-BBB modulation, without exogenous therapeutic, leading to glial plasticity, amyloid pathology reduction, hippocampal neurogenesis and improved cognitive functions in a preclinical model of Alzheimer’s disease (AD). The presentation will conclude with the clinical evaluation of MRIgFUS and BBB modulation in people with AD.


    Isabelle Aubert, PhD

    Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto

  • 10:50 am

  • Updates on Alternative Administration of Peptides: Bioavailability and Capability of Delivering Peptides and Non Small Molecules Through the Oral Route

    • What are the delivery options outside the traditional subcutaneous injections moving forward?
    • What strategies are showing success in improving the oral absorption of peptide-based drugs?

    Randy Mrsny
    Randall Mrsny, PhD

    Professor’s Chair, Department of Pharmacy and Pharmacology, University of Bath

  • 11:10 am

  • Ophthalmology: Exploring Other Routes of Administration

    • Exploring other routes of administration beyond injection to the back of the eye.
      • Long acting implants for the eye or topical delivery to the back of the eye. These are unsolved problems so we would not have to inject patients with an IV injection
    • How important is retinal penetration for efficacy?
    • What are the benefits of different ways of delivering things to the eye and challenges?

    Moderated by:

    James Cunningham
    James Cunningham, PhD

    Executive Director, Drug Delivery, Allergan

    Panelists:


    James E Chastain, PhD

    Executive Director, PK Sciences – Ophthalmology, Novartis Institutes for BioMedical Research, Inc


    Susan Crowell, PhD

    Scientist, Preclinical and Translational PKPD, Genentech


    Viral Kansara, PhD

    VP, Discovery, Clearside Bio

  • 11:50 am

  • Pharma Spotlights on Drug Delivery Needs

    In this session, pharma companies discuss their current needs, partnering philosophy and scouting interests, as related to drug delivery.

    GSK

    Nima Akhavein

    Associate Fellow and Scientific Leader

    Biogen

    Lani Hack

    Engineer I, ASO Formulation Development and Manufacturing

    EMD Serono

    Simon Geißler, PhD
    Director Drug Delivery and Innovation, 
    Healthcare R&D, CPD, Pharmaceutical Technologies

  • 12:35 pm

  • Transforming Cardiovascular Treatment with Pulmonary Delivery: Every Breath You Take is Shot Through the Heart

    • Pioneering a novel approach for treating cardiovascular conditions by the oral inhalation route
    • Will be the ONLY non-invasive, self administered product for acute management of Paroxysmal Atrial Fibrilation, providing rapid cardioversion
    • In Phase 2: Dose dependent conversion observed
    • Working on enhancements to greatly improve speed of delivery


    Carlos Schuler, PhD

    Chief Operating & Technology Officer & Co-Founder, Incarda Therapeutics

  • 12:50 pm

  • Networking Lunch & Partnering Meetings

  • 1:50 pm

  • How to Realize your Next Drug Delivery Innovation: A Practical Guide to Getting your Innovation to Market


    Uri Baruch

    Director, Head of Drug Delivery, Cambridge Design Partners

  • 2:10 pm

  • Delivering an Innovative, Patient-Centric Delivery System as a Result of Strong Collaborations Between Flex and Amgen


    Daniele Fazio
    VP, Design & Engineering, Flex


    William (Bill) Rich

    VP, Final Drug Product Technologies, Amgen


  • Tech Presentations & Partnering

  • 2:30 pm

  • Drug Delivery Presentations

    The afternoon sessions feature companies that will present a wide range of drug delivery technologies, products, or services. These are “quick fire” presentations, with Q&A following each presentation. Throughout the program there are reserved blocks of time for one-on-one partnering meetings to learn more about the technologies and products presented. And for fun, we will have “ice cream delivery” mid way. 

    Chaired By:

    Mitch Zhao, PhD

    Engineering Director, Primary Container and Drug Delivery Systems, Janssen R&D, Johnson & Johnson

    Presenting Companies:

    Battelle

    BioQ Pharma

    Credence MedSystems

    Drug Delivery Experts

    Harro Höfliger

    Ilias Biologics

    Oakwood Labs

    Portal Instruments

    Starpharma

    tesa Labtec

  • 5:00 pm

  • End of Day One & Networking Reception

2019 Agenda

  • 8:30 am

  • Co-Chairs Opening Remarks

    Ann Daugherty
    Ann Daugherty, PhD

    Senior Manager, Drug Delivery, Genentech

    James Cunningham
    James Cunningham, PhD

    Executive Director, Drug Delivery, Allergan


  • Keynotes, Investment Decision Making, Precision Medicine, Digital and Connected Delivery, Nanostructured Materials & Partnering

  • 8:40 am

  • Panel: Investor Perspectives on Drug Delivery Needs and Investments

    • What are VCs investing in, trends they are seeing, competition and concerns  
    • Before VCs invest, what decision making criteria are they using?
    • What VCs think is important and what pharma thinks is important. Those don’t always match up, how can we better align. What are those differences and what are the rationales?
    • Is there a specific revenue target for a startup company that they would look at before making an investment?

    Moderator:


    David Allison, PhD

    Partner, 5am Ventures

    Panelists:


    Colin Cahill, MBA

    VP, Healthcare Investor, Venrock


    Andrew ElBardissi, MD

    Principal, Deerfield Management


    Lori Hu, MBA

    Principal, Vertex Ventures HC


    Aaron Royston, MD, MBA

    Partner, venBio

  • 9:20 am

  • Leveraging Physiology for Bioresponsive Precision Drug Delivery & The Future Impact of Precision Medicine on Drug Delivery

    Spurred by recent advances in materials chemistry, molecular pharmaceutics and nanobiotechnology, stimuli-responsive “smart” systems offer opportunities for precisely delivering drugs in dose-, spatial- and temporal-controlled manners. In this talk, Dr Zhen Gu, UCSF, will discuss: 

    • The ongoing efforts in developing physiological signal-triggered bioinspired drug delivery systems
    • Glucose-responsive synthetic systems for biomimetic delivery of insulin for diabetes treatment 
    • Bioresponsive microneedle patches and vesicle fusion-mediated synthetic beta cells will be emphasized 
    • Local and targeted delivery of immunomodulatory therapeutics for enhanced cancer therapy 
    • An introduction to their latest study utilizing platelets, cell conjugates and sprayable gels for delivery of immune checkpoint inhibitors 
    • Insights on the future of precision medicine and the impact on drug delivery moving forward


    Zhen Gu, PhD

    Professor, Department of Bioengineering, California NanoSystems Institute (CNSI)University of California, Los Angeles (UCLA)

  • 9:50 am

  • Morning Networking Break & Partnering Meetings

  • 10:35 am

  • Keynote: Nanostructured Materials for Enhanced Therapeutic Delivery


    Tejal Desai, PhD

    Ernest L. Prien Endowed Professor and Chair, Department of Bioengineering and Therapeutic Sciences, UCSF Schools of Pharmacy and Medicine

  • 11:05 am

  • Industry Keynote: The Digital and Connected Health Ecosystem: Incorporating Wellness into the Pharma Model and How Drug Delivery will be a Key Enabler

    Justin Wright 2018
    Justin M Wright, PhD

    Global Head of Innovation, Novartis

  • 11:35 am

  • Connected Device Systems that Span Multiple Regulatory Classifications


    Kimberly Ringenberger, PhD

    Associate Engineering Advisor, Eli Lilly

  • 12:05 pm

  • Advancing the Connected and Smart Drug Delivery Ecosystem: A Path Forward

    The connected drug delivery device market is expected to grow tremendously with emerging technologies that connect patients, physicians, researchers, health systems, etc, while reducing burden to all. Drug delivery manufacturers of inhalers to treat asthma and chronic lung disease for example are fast developing the next generation of smart devices with sensors to monitor if patients are using their devices correctly. In this panel discussion, we focus on next generation emerging technologies, design needs and challenges, and regulatory hurdles to advance the drug delivery smart and connected world.

    Moderated by:
    Justin Wright 2018
    Justin M Wright, PhD

    Global Head of Innovation, Novartis

    Panelists:


    Kimberly Ringenberger, PhD

    Associate Engineering Advisor, Eli Lilly


    Rajan Patel

    CEO and Founder, iO Life Science


    Dirk Schapeler

    VP, Digital Innovation, Bayer Healthcare

  • 1:00 pm

  • Networking Lunch and Partnering Meetings


  • Early Stage Technologies and Evaluations

  • 2:00 pm

  • Early Stage Technology Showcase

    This session features five-minute talks on cutting-edge technologies, inventions and ideas. The showcase is open to start-up companies, entrepreneurs, investors, licensing officers and university researchers.

    Chaired by:


    Jason Olbrich, PhD

    Principal Engineer, Final Product Technologies, Amgen

    Presenting Companies:

    Adepthera, LLC

    Cinti Medical, Inc

    Quench Medical

  • 2:40 pm

  • How do we Overcome the Barriers of Getting New Technologies Evaluated and Brought in earlier in Product Development?

    Pharma companies often face challenges when it comes to working with external drug delivery technologies as a result of cost and resources. Because pharma’s primary focus is developing molecules, developing drug delivery strategies doesn’t always get worked into the pipeline early enough.This panel will delve into the following:

    • How can we get drug delivery technologies earlier in the pipeline development of molecules?
    • How can we lower the upfront risks?
    • What are the work arounds?

    Moderator:
    Ann Daugherty
    Ann Daugherty, PhD

    Senior Manager, Drug Delivery, Genentech

    Panelists:


    Nima Akhavein

    Associate Fellow and Scientific Leader, GSK


    Jason Olbrich, PhD

    Principal Engineer, Final Product Technologies, Amgen


    Andrew Ratz

    Senior Director, Delivery, Device & Connected Solutions, Eli Lilly

  • 3:25 pm

  • End of Day Two